The company’s core technology is based on its revolutionary biomarkers that covers both cells (MDSCs) and protein (CD247 & SNX9) levels. It was demonstrated that MDSC levels are upregulated and CD247 & SNX9 are down-regulated in chronic inflammatory conditions, leading to immune dysfunction.
The uniqueness of these biomarkers and the fact that they hold a different sensitivity to the inflammatory environment, enable different combinations between them that can offer reliable and validated solutions for identifying chronic inflammation and impaired immune status associated with numerous chronic diseases.
CD247 (also known as ζ-chain)
A protein expressed mainly in hematopoietic cells and serves as part of the T-cell’s main receptor and receptors expressed on NK cells. CD247 is a transmembrane molecule, with an extremely short extracellular domain of 9 amino acids and a long intracellular region composed of 113 amino acids, which enable the transmission of several signal-transduction pathways upon antigen recognition. CD247 plays a unique and vital role in T- and NK-cell activation and effector functions. Low CD247 expression levels result in impaired T- and NK-cell-mediated immune responses. Improdia has shown that a chronic inflammatory environment induces down-regulation of CD247 expression and impairment of T- and NK-cell functions, leading to suppression of the immune response.
MDSCs – Myeloid Derived Suppressor Cells
Immature cells, proliferates during chronic inflammation
they are up regulated in the spleen and BM (Bone Marrow) during chronic inflammation
Markers for human immature MDSCs
SNX9: Sorting nexin-9
A protein expressed in many cell types including hematopoietic stem cells. It contains several binding domains and in the past few years has been identified as an important protein participating in fundamental cellular activities such as plasma membrane receptors trafficking, internalization and degradation. Improdia showed that inflammatory environment induces down-regulation of SNX9.